MIFEPRISTONE+MISOPROSTOL belongs to a group of gynaecological medications called ‘Abortifacient’ used for the medical termination of the pregnancy before 63 days after the first day of the last menses period. Second Step also works in the second trimester of pregnancy.

Second Step contains two medicines, namely: Mifepristone and Misoprostol. Mifepristone is an anti-hormone (anti-progestogen) that blocks the effects of the progesterone hormone required in women to continue the pregnancy. On the other hand, Misoprostol is a prostaglandin that increases the womb’s (uterus) contraction and dilates the cervix, thereby expelling the pregnancy. Thus, MIFEPRISTONE+MISOPROSTOL together cause termination of pregnancy and must be used one after the other for medical abortion.

A medical abortion generally involves 2-3 visits to a doctor or clinic, which includes giving medicines and then confirmation of termination of pregnancy. Following are the schedule involved in medical abortion:

• Day 1: Medical counselling and examination where doctor instructs to take one tablet of mifepristone (200 mcg)
• Day 2 to 3: You must return to the hospital/clinic 36 to 48 hours after taking the first dose of mifepristone. Your doctor will tell you about this. The tablet of Misoprostol (800 mcg) will now be given either orally or vaginally.
• Day 7 to 14: The doctor will confirm and make sure whether the medical abortion has been completed or not. If the abortion is not complete, you might require more follow-up visits.

In some cases, you may experience nausea, uterine cramps, vomiting, diarrhoea, infection following abortion, dizziness, and uterine bleeding. Most of these side effects of Second Step subside with time. But if vaginal bleeding does not stop, please visit the doctor immediately, as it requires immediate medical attention.

Second Step should not be stopped abruptly without consulting the doctor as it may lead to incomplete abortion. Inform your doctor before starting Second Step if you have had an ectopic pregnancy (when the womb grows in the fallopian tube), using an intrauterine device, or you are breastfeeding, any bleeding disorder or heart problem. Do not strenuous activities like running, heavy exercise, or driving to avoid excessive bleeding. The doctor will also check with ultrasound if the absorption is complete as no bleeding does not mean that abortion is complete.

Uses of Second Step - MIFEPRISTONE+MISOPROSTOL:

Medical abortion

Medicinal Benefits: Second Step contains Mifepristone and Misoprostol. Mifepristone works by blocking the effect of progesterone (female hormone) needed to maintain a pregnancy. In the absence of progesterone, the lining of the uterus breaks down as it does every month during the menstrual cycle, and the growth of pregnancy is stopped. It takes approximately 24-48 hours for Second Step to show effect. Once it starts acting, you will experience uterine bleeding. But no uterine bleeding does not mean that the abortion is complete. On the other hand, the second medicine is Misoprostol, a prostaglandin analogue that helps increase uterine contractions and relaxes the cervix. Thus Together MIFEPRISTONE+MISOPROSTOL terminates the state of pregnancy. Misoprostol should be taken at least 24-36 hours after taking mifepristone, either orally or vaginally. This is a non-surgical method which is 90% successful.

Directions for Use:

Second Step should be taken in dose and duration as prescribed by your doctor.

Storage:

Store in a cool and dry place away from sunlight.

Other Information:

Packing: Each combi-pack contains (Mifepristone Tablets – 1 Tablet and Misoprostol Tablets – 4 Tablets)
Delivery lead Time: Immediate.
Port of Dispatch: Mumbai.
Mode of Export: Air Cargo/Sea Cargo/Door Delivery Cargo Couriers.
Payment terms: Bank wire terms/Letter of Credit.